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To ensure that you get the latest version please visit the Assetto Corsa Competizione homepage.Acute myeloid leukemia patients undergoing autologous stem cell transplantation display no significant improvement of the donor/recipient HLA-A, -B, and -DR incompatibility effect on time to relapse and survival.
Previous studies have shown that an acute myeloid leukemia (AML) patient’s survival may be prolonged by a HLA-A, -B, and/or -DR incompatibility in the bone marrow (BM) donor/recipient pair. However, the impact of this finding on clinical outcomes following allogeneic stem cell transplantation (SCT) is unknown. Allogeneic SCT is superior to autologous SCT in most patients, but the survival benefit depends on the human leukocyte antigen (HLA) class I incompatibility effect. We retrospectively analyzed the impact of HLA incompatibility on time to relapse and survival in an unselected patient cohort that underwent autologous or allogeneic SCT. Of 763 patients with AML and their BM donor/recipient pairs, 238 (31.2%) had HLA-A, -B, and/or -DR incompatibility. HLA-A, -B, and/or -DR incompatibility was found in 72.7% of patients that underwent autologous SCT, and in 52.1% of patients that underwent allogeneic SCT. HLA-A, -B, and/or -DR incompatibility was not associated with time to relapse or survival in patients undergoing autologous SCT or allogeneic SCT. Therefore, the development of an HLA-A, -B, and/or

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